null
SMILES: [#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7]
InChI Key: InChIKey=YAOAMZOGXBMLFQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Deoxyhypusine synthase (Plasmodium falciparum) | BDBM50216786![]() (CHEMBL229457 | N-(7-Amino-heptyl)-guanidine | N-gu...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Parasitology Curated by ChEMBL | Assay Description Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF54 | Bioorg Med Chem 15: 6200-7 (2007) Article DOI: 10.1016/j.bmc.2007.06.026 BindingDB Entry DOI: 10.7270/Q20Z7305 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyhypusine synthase (Homo sapiens) | BDBM50216786![]() (CHEMBL229457 | N-(7-Amino-heptyl)-guanidine | N-gu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Competitive inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction i... | J Med Chem 63: 3215-3226 (2020) Article DOI: 10.1021/acs.jmedchem.9b01979 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyhypusine synthase (Homo sapiens) | BDBM50216786![]() (CHEMBL229457 | N-(7-Amino-heptyl)-guanidine | N-gu...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel... | J Med Chem 63: 3215-3226 (2020) Article DOI: 10.1021/acs.jmedchem.9b01979 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyhypusine synthase (Rattus norvegicus) | BDBM50216786![]() (CHEMBL229457 | N-(7-Amino-heptyl)-guanidine | N-gu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | MMDB PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Dental Research Curated by ChEMBL | Assay Description In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase. | J Med Chem 38: 3053-61 (1995) BindingDB Entry DOI: 10.7270/Q2P55MJ2 | |||||||||||
More data for this Ligand-Target Pair |