Found 4 hits for monomerid = 50221984 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase VIII
(Homo sapiens (Human)) | BDBM50221984
((2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-...)Show SMILES C[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)C1CCC(CC1)c1cccnc1 |wU:2.2,wD:1.0,(21.02,4.01,;21.02,2.47,;22.36,1.7,;22.36,.16,;23.69,2.47,;23.69,4.01,;25.03,1.7,;26.43,2.32,;27.46,1.17,;26.68,-.16,;25.9,-1.49,;28.19,-.48,;25.17,.16,;19.68,1.7,;19.68,.15,;18.35,-.61,;17.02,.15,;17.02,1.7,;18.35,2.47,;15.69,-.62,;14.36,.14,;13.03,-.63,;13.03,-2.17,;14.37,-2.93,;15.69,-2.16,)| Show InChI InChI=1S/C19H27F2N3O/c1-13(17(22)18(25)24-10-8-19(20,21)12-24)14-4-6-15(7-5-14)16-3-2-9-23-11-16/h2-3,9,11,13-15,17H,4-8,10,12,22H2,1H3/t13-,14?,15?,17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DPP8 |
Bioorg Med Chem Lett 17: 5806-11 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.049 BindingDB Entry DOI: 10.7270/Q2251HXN |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 9
(Homo sapiens (Human)) | BDBM50221984
((2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-...)Show SMILES C[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)C1CCC(CC1)c1cccnc1 |wU:2.2,wD:1.0,(21.02,4.01,;21.02,2.47,;22.36,1.7,;22.36,.16,;23.69,2.47,;23.69,4.01,;25.03,1.7,;26.43,2.32,;27.46,1.17,;26.68,-.16,;25.9,-1.49,;28.19,-.48,;25.17,.16,;19.68,1.7,;19.68,.15,;18.35,-.61,;17.02,.15,;17.02,1.7,;18.35,2.47,;15.69,-.62,;14.36,.14,;13.03,-.63,;13.03,-2.17,;14.37,-2.93,;15.69,-2.16,)| Show InChI InChI=1S/C19H27F2N3O/c1-13(17(22)18(25)24-10-8-19(20,21)12-24)14-4-6-15(7-5-14)16-3-2-9-23-11-16/h2-3,9,11,13-15,17H,4-8,10,12,22H2,1H3/t13-,14?,15?,17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DPP9 |
Bioorg Med Chem Lett 17: 5806-11 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.049 BindingDB Entry DOI: 10.7270/Q2251HXN |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50221984
((2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-...)Show SMILES C[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)C1CCC(CC1)c1cccnc1 |wU:2.2,wD:1.0,(21.02,4.01,;21.02,2.47,;22.36,1.7,;22.36,.16,;23.69,2.47,;23.69,4.01,;25.03,1.7,;26.43,2.32,;27.46,1.17,;26.68,-.16,;25.9,-1.49,;28.19,-.48,;25.17,.16,;19.68,1.7,;19.68,.15,;18.35,-.61,;17.02,.15,;17.02,1.7,;18.35,2.47,;15.69,-.62,;14.36,.14,;13.03,-.63,;13.03,-2.17,;14.37,-2.93,;15.69,-2.16,)| Show InChI InChI=1S/C19H27F2N3O/c1-13(17(22)18(25)24-10-8-19(20,21)12-24)14-4-6-15(7-5-14)16-3-2-9-23-11-16/h2-3,9,11,13-15,17H,4-8,10,12,22H2,1H3/t13-,14?,15?,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 |
Bioorg Med Chem Lett 17: 5806-11 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.049 BindingDB Entry DOI: 10.7270/Q2251HXN |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50221984
((2S,3S)-2-amino-1-(3,3-difluoropyrrolidin-1-yl)-3-...)Show SMILES C[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)C1CCC(CC1)c1cccnc1 |wU:2.2,wD:1.0,(21.02,4.01,;21.02,2.47,;22.36,1.7,;22.36,.16,;23.69,2.47,;23.69,4.01,;25.03,1.7,;26.43,2.32,;27.46,1.17,;26.68,-.16,;25.9,-1.49,;28.19,-.48,;25.17,.16,;19.68,1.7,;19.68,.15,;18.35,-.61,;17.02,.15,;17.02,1.7,;18.35,2.47,;15.69,-.62,;14.36,.14,;13.03,-.63,;13.03,-2.17,;14.37,-2.93,;15.69,-2.16,)| Show InChI InChI=1S/C19H27F2N3O/c1-13(17(22)18(25)24-10-8-19(20,21)12-24)14-4-6-15(7-5-14)16-3-2-9-23-11-16/h2-3,9,11,13-15,17H,4-8,10,12,22H2,1H3/t13-,14?,15?,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 in presence of 50 % human serum |
Bioorg Med Chem Lett 17: 5806-11 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.049 BindingDB Entry DOI: 10.7270/Q2251HXN |
More data for this Ligand-Target Pair | |