BDBM50224115 CHEMBL238033::ethyl-2-Methyl-1-[4-(methylsulfonyl)phenyl]-5-[4-(trifluoro)phenyl]-1H-pyrrol-3-acetate

SMILES: CCOC(=O)Cc1cc(-c2ccc(cc2)C(F)(F)F)n(c1C)-c1ccc(cc1)S(C)(=O)=O

InChI Key: InChIKey=MACPERMNSNWSPB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224115   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase (cyclooxygenase) (Mus musculus)	BDBM50224115 (CHEMBL238033 | ethyl-2-Methyl-1-[4-(methylsulfonyl...) Show SMILES CCOC(=O)Cc1cc(-c2ccc(cc2)C(F)(F)F)n(c1C)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C23H22F3NO4S/c1-4-31-22(28)14-17-13-21(16-5-7-18(8-6-16)23(24,25)26)27(15(17)2)19-9-11-20(12-10-19)32(3,29)30/h5-13H,4,14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università La Sapienza Curated by ChEMBL					Assay Description Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassay				J Med Chem 50: 5403-11 (2007) Article DOI: 10.1021/jm0707525 BindingDB Entry DOI: 10.7270/Q2PK0FV8
					More data for this Ligand-Target Pair