BDBM50225085 2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)ethyl)piperazin-1-yl)-N,N-dimethylacetamide::CHEMBL401193
SMILES: CN(C)C(=O)CN1CCN(CCc2c([nH]c3sc(cc23)C(C)(C)C(=O)N2C3CCC2CC3)-c2cc(C)cc(C)c2)CC1
InChI Key: InChIKey=VPZCRWKFXSQLLK-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human)) | BDBM50225085 (2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches Curated by ChEMBL | Assay Description Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells | Bioorg Med Chem Lett 17: 6448-54 (2007) Article DOI: 10.1016/j.bmcl.2007.09.099 BindingDB Entry DOI: 10.7270/Q26D5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50225085 (2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches Curated by ChEMBL | Assay Description Displacement of [125I]D-Trp from rat GnRH receptor | Bioorg Med Chem Lett 17: 6448-54 (2007) Article DOI: 10.1016/j.bmcl.2007.09.099 BindingDB Entry DOI: 10.7270/Q26D5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human)) | BDBM50225085 (2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches Curated by ChEMBL | Assay Description Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pitutary cells assessed as inhibition of GnRH stimulated LH release after... | Bioorg Med Chem Lett 17: 6448-54 (2007) Article DOI: 10.1016/j.bmcl.2007.09.099 BindingDB Entry DOI: 10.7270/Q26D5SQF | |||||||||||
More data for this Ligand-Target Pair |