BDBM50225275 CHEMBL238659::H-imidazo[2,1-a]isoquinoline-2-carbohydrazide::IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE

SMILES: NNC(=O)c1cn2ccc3ccccc3c2n1

InChI Key: InChIKey=WSNWYZBDIKCPIG-UHFFFAOYSA-N

Data: 6 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50225275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	4.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Manganese				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 6 uM Iron				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 5 uM Manganese				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 1 uM Cobalt				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Cobalt				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine Aminopeptidase (MAP) (Escherichia coli (strain K12))	BDBM50225275 (CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...) Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1 Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank MMDB PDB Article PubMed	n/a	n/a	6.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Inhibition of Escherichia coli methionine aminopeptidase in presence of 10 uM Nickel				J Med Chem 50: 5735-42 (2007) Article DOI: 10.1021/jm700930k BindingDB Entry DOI: 10.7270/Q2JQ10R2
					More data for this Ligand-Target Pair				3D Structure (crystal)