BDBM50227722 CHEMBL398641::N-hydroxy-2-{4-[3'-(2-hydroxy-ethoxy)-2-methyl-biphenyl-4-yl]-piperidine-1-sulfonyl}-2-methyl-propionamide

SMILES: Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO

InChI Key: InChIKey=XMVZJCLXRBLZHB-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50227722   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50227722 (CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethox...) Show SMILES Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO Show InChI InChI=1S/C24H32N2O6S/c1-17-15-19(7-8-22(17)20-5-4-6-21(16-20)32-14-13-27)18-9-11-26(12-10-18)33(30,31)24(2,3)23(28)25-29/h4-8,15-16,18,27,29H,9-14H2,1-3H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50227722 (CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethox...) Show SMILES Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO Show InChI InChI=1S/C24H32N2O6S/c1-17-15-19(7-8-22(17)20-5-4-6-21(16-20)32-14-13-27)18-9-11-26(12-10-18)33(30,31)24(2,3)23(28)25-29/h4-8,15-16,18,27,29H,9-14H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	406	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP9				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50227722 (CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethox...) Show SMILES Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO Show InChI InChI=1S/C24H32N2O6S/c1-17-15-19(7-8-22(17)20-5-4-6-21(16-20)32-14-13-27)18-9-11-26(12-10-18)33(30,31)24(2,3)23(28)25-29/h4-8,15-16,18,27,29H,9-14H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50227722 (CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethox...) Show SMILES Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO Show InChI InChI=1S/C24H32N2O6S/c1-17-15-19(7-8-22(17)20-5-4-6-21(16-20)32-14-13-27)18-9-11-26(12-10-18)33(30,31)24(2,3)23(28)25-29/h4-8,15-16,18,27,29H,9-14H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	262	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50227722 (CHEMBL398641 | N-hydroxy-2-{4-[3'-(2-hydroxy-ethox...) Show SMILES Cc1cc(ccc1-c1cccc(OCCO)c1)C1CCN(CC1)S(=O)(=O)C(C)(C)C(=O)NO Show InChI InChI=1S/C24H32N2O6S/c1-17-15-19(7-8-22(17)20-5-4-6-21(16-20)32-14-13-27)18-9-11-26(12-10-18)33(30,31)24(2,3)23(28)25-29/h4-8,15-16,18,27,29H,9-14H2,1-3H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair