BDBM50229216 CHEMBL254742::N-(4-(2-hydroxy-3,4-dioxocyclobut-1-enyl)benzyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamide

SMILES: Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=XICWOOPHRLYMIR-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50229216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human))	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARgamma assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma (Mus musculus)	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50229216 (CHEMBL254742 | N-(4-(2-hydroxy-3,4-dioxocyclobut-1...) Show SMILES Cc1nc(sc1C(=O)NCc1ccc(cc1)-c1c(O)c(=O)c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H15F3N2O4S/c1-11-20(33-22(28-11)14-6-8-15(9-7-14)23(24,25)26)21(32)27-10-12-2-4-13(5-3-12)16-17(29)19(31)18(16)30/h2-9,29H,10H2,1H3,(H,27,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
					More data for this Ligand-Target Pair