BindingDB PrimarySearch

BDBM50229666 (2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidine-5-carboxamido)-3-methylpentanoic acid::CHEMBL214381::Ile-Pro-Ile

SMILES: CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

InChI Key: InChIKey=JNTMAZFVYNDPLB-PEDHHIEDSA-N

Data: 3 KI 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50229666
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of DPP-4 (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 min				Med Chem Res 21: 1445-1450 (2012) Article DOI: 10.1007/s00044-011-9666-5 BindingDB Entry DOI: 10.7270/Q2NP27BJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of DPP-4 (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 min				Med Chem Res 21: 1445-1450 (2012) Article DOI: 10.1007/s00044-011-9666-5 BindingDB Entry DOI: 10.7270/Q2NP27BJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP8 assessed as Gly-Pro-pNA chromogrnic substrate cleavage for 16 mins preincubated with compound for 10 mins before...				ACS Med Chem Lett 1: 530-535 (2010) Article DOI: 10.1021/ml100200c BindingDB Entry DOI: 10.7270/Q2513ZGH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase IV (Sus scrofa (pig))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	1.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. John's University Curated by ChEMBL					Assay Description Inhibition of pig DPP4				Bioorg Med Chem Lett 18: 479-84 (2008) Article DOI: 10.1016/j.bmcl.2007.11.107 BindingDB Entry DOI: 10.7270/Q27W6BX8
St. John's University Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	4.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins ...				Eur J Med Chem 151: 145-157 (2018) Article DOI: 10.1016/j.ejmech.2018.03.041 BindingDB Entry DOI: 10.7270/Q2CZ39SV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of DPP4 in human plasma using Gly-Pro-AMC substrate incubated for 20 mins by fluorometry				Bioorg Med Chem 22: 6515-22 (2015) Article DOI: 10.1016/j.bmc.2014.06.051 BindingDB Entry DOI: 10.7270/Q21Z4611
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50229666 ((2S,3S)-2-((S)-1-((2S,3S)-2-amino-3-methylpentanoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA chromogrnic substrate cleavage for 16 mins preincubated with compound for 10 mins before...				ACS Med Chem Lett 1: 530-535 (2010) Article DOI: 10.1021/ml100200c BindingDB Entry DOI: 10.7270/Q2513ZGH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair