BDBM50232361 CHEMBL4084222

SMILES: CN1CCc2c(C1)c1ccccc1n2Cc1ccc(\C=C\C(=O)NO)cc1

InChI Key: InChIKey=RASYOKNLFDNVTL-ZHACJKMWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50232361 (CHEMBL4084222) Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(\C=C\C(=O)NO)cc1 Show InChI InChI=1S/C22H23N3O2/c1-24-13-12-21-19(15-24)18-4-2-3-5-20(18)25(21)14-17-8-6-16(7-9-17)10-11-22(26)23-27/h2-11,27H,12-15H2,1H3,(H,23,26)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 expressed in insect cells using RHKK(Ac) as substrate after 60 mins by fluori...				Eur J Med Chem 127: 115-127 (2017) BindingDB Entry DOI: 10.7270/Q20K2BT4
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50232361 (CHEMBL4084222) Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(\C=C\C(=O)NO)cc1 Show InChI InChI=1S/C22H23N3O2/c1-24-13-12-21-19(15-24)18-4-2-3-5-20(18)25(21)14-17-8-6-16(7-9-17)10-11-22(26)23-27/h2-11,27H,12-15H2,1H3,(H,23,26)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 expressed in Sf21 cells using RHKK(Ac) as substrate after 60 mins by flu...				Eur J Med Chem 127: 115-127 (2017) BindingDB Entry DOI: 10.7270/Q20K2BT4
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50232361 (CHEMBL4084222) Show SMILES CN1CCc2c(C1)c1ccccc1n2Cc1ccc(\C=C\C(=O)NO)cc1 Show InChI InChI=1S/C22H23N3O2/c1-24-13-12-21-19(15-24)18-4-2-3-5-20(18)25(21)14-17-8-6-16(7-9-17)10-11-22(26)23-27/h2-11,27H,12-15H2,1H3,(H,23,26)/b11-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in Sf9 cells using RHKK(Ac) as substrate after 90 mins by fluorimet...				Eur J Med Chem 127: 115-127 (2017) BindingDB Entry DOI: 10.7270/Q20K2BT4
					More data for this Ligand-Target Pair