null

SMILES: Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1

InChI Key: InChIKey=LZGJJVGDHDDRLZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50234519   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50234519 (4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...) Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	306	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of IGF1R expressed in SAL cells				Bioorg Med Chem Lett 18: 1702-7 (2008) Article DOI: 10.1016/j.bmcl.2008.01.049 BindingDB Entry DOI: 10.7270/Q2NV9J1M
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50234519 (4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...) Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...				Bioorg Med Chem Lett 20: 1744-8 (2010) Article DOI: 10.1016/j.bmcl.2010.01.087 BindingDB Entry DOI: 10.7270/Q2MW2H95
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50234519 (4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...) Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 18: 1702-7 (2008) Article DOI: 10.1016/j.bmcl.2008.01.049 BindingDB Entry DOI: 10.7270/Q2NV9J1M
					More data for this Ligand-Target Pair