BDBM50234674 CHEMBL4086384

SMILES: OC(=O)c1[nH]c2cc(Cl)ccc2c1C(NCC1CCCCC1)c1nnnn1-c1ccc(Cl)cc1

InChI Key: InChIKey=JBVUBUHDQUZJTO-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50234674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50234674 (CHEMBL4086384) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1C(NCC1CCCCC1)c1nnnn1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24Cl2N6O2/c25-15-6-9-17(10-7-15)32-23(29-30-31-32)21(27-13-14-4-2-1-3-5-14)20-18-11-8-16(26)12-19(18)28-22(20)24(33)34/h6-12,14,21,27-28H,1-5,13H2,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDM2 (1 to 118 residues) expressed in Escherichia coli BL21(DE3) measur...				Eur J Med Chem 126: 384-407 (2017) BindingDB Entry DOI: 10.7270/Q2JQ1381
					More data for this Ligand-Target Pair
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM50234674 (CHEMBL4086384) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1C(NCC1CCCCC1)c1nnnn1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24Cl2N6O2/c25-15-6-9-17(10-7-15)32-23(29-30-31-32)21(27-13-14-4-2-1-3-5-14)20-18-11-8-16(26)12-19(18)28-22(20)24(33)34/h6-12,14,21,27-28H,1-5,13H2,(H,33,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of 5'--FAM-LTFEHYWAQLTS peptide binding to N-terminal domain human MDMX (1 to 134 residues) measured after 15 mins by fluorescence polariz...				Eur J Med Chem 126: 384-407 (2017) BindingDB Entry DOI: 10.7270/Q2JQ1381
					More data for this Ligand-Target Pair