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BDBM50237110 CHEMBL4062528

SMILES: Brc1cccc(Nc2ncnc3ccc(NC(=S)N4CCOCC4)cc23)c1

InChI Key: InChIKey=OFWUKDGVIIOQRP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50237110   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50237110
PNG
(CHEMBL4062528)
Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)N4CCOCC4)cc23)c1
Show InChI InChI=1S/C19H18BrN5OS/c20-13-2-1-3-14(10-13)23-18-16-11-15(4-5-17(16)21-12-22-18)24-19(27)25-6-8-26-9-7-25/h1-5,10-12H,6-9H2,(H,24,27)(H,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system


J Med Chem 60: 2853-2868 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP
More data for this
Ligand-Target Pair