BDBM50238061 CHEMBL4092523

SMILES: Cc1ccc(F)c(c1)-c1cc(Nc2ccnc3cn[nH]c23)ccn1

InChI Key: InChIKey=HRCGVNUAOAEEHK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50238061 (CHEMBL4092523) Show SMILES Cc1ccc(F)c(c1)-c1cc(Nc2ccnc3cn[nH]c23)ccn1 Show InChI InChI=1S/C18H14FN5/c1-11-2-3-14(19)13(8-11)16-9-12(4-6-20-16)23-15-5-7-21-17-10-22-24-18(15)17/h2-10H,1H3,(H,22,24)(H,20,21,23)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...				Bioorg Med Chem Lett 27: 1955-1961 (2017) Article DOI: 10.1016/j.bmcl.2017.03.026 BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
					More data for this Ligand-Target Pair