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BDBM50239265 CHEMBL4073410

SMILES: O[C@H]1[C@H](O)[C@@]2(CO[C@@](O2)([C@@H]1O)c1ccc(Cl)c(Cc2ccc(O[C@H]3CCOC3)cc2)c1)OC(F)F

InChI Key: InChIKey=PPJUFJBHZWDNET-LKNJQJTNSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50239265   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50239265
PNG
(CHEMBL4073410)
Show SMILES O[C@H]1[C@H](O)[C@@]2(CO[C@@](O2)([C@@H]1O)c1ccc(Cl)c(Cc2ccc(O[C@H]3CCOC3)cc2)c1)OC(F)F |r|
Show InChI InChI=1S/C24H25ClF2O8/c25-18-6-3-15(24-21(30)19(28)20(29)23(35-24,12-32-24)34-22(26)27)10-14(18)9-13-1-4-16(5-2-13)33-17-7-8-31-11-17/h1-6,10,17,19-22,28-30H,7-9,11-12H2/t17-,19-,20-,21+,23-,24-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



Haisco Pharmaceuticals Group Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount method

J Med Chem 60: 4173-4184 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01818
BindingDB Entry DOI: 10.7270/Q2W37ZFS
More data for this
Ligand-Target Pair