BDBM50241754 CHEMBL4077894
SMILES: Cl.CCOc1ccc(Cl)c2[C@@H](CN)OB(O)c12
InChI Key: InChIKey=RNWXGTCHQYEZGU-DDWIOCJRSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leucyl-tRNA synthetase (Homo sapiens (Human)) | BDBM50241754 (CHEMBL4077894) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine ad... | J Med Chem 60: 8011-8026 (2017) Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable leucine--tRNA ligase, mitochondrial (Homo sapiens) | BDBM50241754 (CHEMBL4077894) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of human N-terminal 6His-tagged mitochondrial LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to... | J Med Chem 60: 8011-8026 (2017) Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucyl-tRNA synthetase (Homo sapiens (Human)) | BDBM50241754 (CHEMBL4077894) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E... | J Med Chem 60: 8011-8026 (2017) Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine--tRNA ligase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50241754 (CHEMBL4077894) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand. | J Med Chem 60: 8011-8026 (2017) Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH | |||||||||||
More data for this Ligand-Target Pair |