BDBM50242374 CHEMBL505529::topostatin
SMILES: CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C
InChI Key: InChIKey=XLDIAUNLPWGNHO-KNNFRUAVSA-N
Data: 18 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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DNA topoisomerase (Bos taurus) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition calf thymus gland topoisomerase 1 assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of telomerase from human COLO201 cell | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 1 (Cercopithecus aethiops) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase II alpha (HuTopoIIα) (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase II alpha (HuTopoIIα) (Homo sapiens (Human)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomer | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CAM-RNase A (Bison bison (American bison)) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyribonuclease-1 (Bos taurus) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of bovine pancreas DNase 1 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyribonuclease-2-alpha (Sus scrofa) | BDBM50242374 (CHEMBL505529 | topostatin) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of porcine spleen DNase 2 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bacteriophage T4 DNA Ligase (Bacteriophage T4) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of T4 ligase from bacteriophage infected Escherichia coli assessed as ligation of supercoiled pBR322 DNA | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 restriction enzyme BamHI (Bacillus amyloliquefaciens) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of Bacillus amyloliquifaction Bam H1 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 restriction enzyme EcoRI (Escherichia coli) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of Escherichia coli Eco R1 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 restriction enzyme HindIII (Haemophilus influenzae) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 restriction enzyme PstI (Providencia stuartii) | BDBM50242374 (CHEMBL505529 | topostatin) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of Providencia stuartii Pst 1 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 restriction enzyme ScaI (Streptomyces caespitosus) | BDBM50242374 (CHEMBL505529 | topostatin) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentration | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Mus musculus) | BDBM50242374 (CHEMBL505529 | topostatin) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
More data for this Ligand-Target Pair |