BDBM50243471 1-(3-carbamoyl-5-(4-((2,2,6,6-tetramethylpiperidin-1-yl)methyl)phenyl)thiophen-2-yl)urea::CHEMBL460685

SMILES: CC1(C)CCCC(C)(C)N1Cc1ccc(cc1)-c1cc(C(N)=O)c(NC(N)=O)s1

InChI Key: InChIKey=SCAXNJNEJGAKKP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50243471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50243471 (1-(3-carbamoyl-5-(4-((2,2,6,6-tetramethylpiperidin...) Show SMILES CC1(C)CCCC(C)(C)N1Cc1ccc(cc1)-c1cc(C(N)=O)c(NC(N)=O)s1 Show InChI InChI=1S/C22H30N4O2S/c1-21(2)10-5-11-22(3,4)26(21)13-14-6-8-15(9-7-14)17-12-16(18(23)27)19(29-17)25-20(24)28/h6-9,12H,5,10-11,13H2,1-4H3,(H2,23,27)(H3,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of Chk1				Bioorg Med Chem Lett 18: 4242-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.016 BindingDB Entry DOI: 10.7270/Q2J102Z9
					More data for this Ligand-Target Pair