BDBM50243780 2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)ethanone::CHEMBL447168

SMILES: CN(C)CC(=O)N1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key: InChIKey=IPKCBFKZZCKGDL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243780   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243780 (2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyri...) Show SMILES CN(C)CC(=O)N1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C40H43N11O/c1-48(2)27-35(52)50-20-22-51(23-21-50)40-42-25-32-24-33(29-8-4-3-5-9-29)36(43-37(32)45-40)30-13-11-28(12-14-30)26-49-18-15-31(16-19-49)38-44-39(47-46-38)34-10-6-7-17-41-34/h3-14,17,24-25,31H,15-16,18-23,26-27H2,1-2H3,(H,44,46,47)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243780 (2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyri...) Show SMILES CN(C)CC(=O)N1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C40H43N11O/c1-48(2)27-35(52)50-20-22-51(23-21-50)40-42-25-32-24-33(29-8-4-3-5-9-29)36(43-37(32)45-40)30-13-11-28(12-14-30)26-49-18-15-31(16-19-49)38-44-39(47-46-38)34-10-6-7-17-41-34/h3-14,17,24-25,31H,15-16,18-23,26-27H2,1-2H3,(H,44,46,47)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243780 (2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyri...) Show SMILES CN(C)CC(=O)N1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C40H43N11O/c1-48(2)27-35(52)50-20-22-51(23-21-50)40-42-25-32-24-33(29-8-4-3-5-9-29)36(43-37(32)45-40)30-13-11-28(12-14-30)26-49-18-15-31(16-19-49)38-44-39(47-46-38)34-10-6-7-17-41-34/h3-14,17,24-25,31H,15-16,18-23,26-27H2,1-2H3,(H,44,46,47)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243780 (2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyri...) Show SMILES CN(C)CC(=O)N1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C40H43N11O/c1-48(2)27-35(52)50-20-22-51(23-21-50)40-42-25-32-24-33(29-8-4-3-5-9-29)36(43-37(32)45-40)30-13-11-28(12-14-30)26-49-18-15-31(16-19-49)38-44-39(47-46-38)34-10-6-7-17-41-34/h3-14,17,24-25,31H,15-16,18-23,26-27H2,1-2H3,(H,44,46,47)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair