BDBM50245377 3-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-4-fluorobenzamide::CHEMBL462003

SMILES: COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(F)c(Cl)c5)nn(C)c4c3)c2cc1OC

InChI Key: InChIKey=GUWVBQMRCXNYMQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50245377   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50245377 (3-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-me...) Show SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)c5ccc(F)c(Cl)c5)nn(C)c4c3)c2cc1OC Show InChI InChI=1S/C26H20ClFN4O4/c1-32-21-11-15(36-22-8-9-29-20-13-24(35-3)23(34-2)12-17(20)22)5-6-16(21)25(31-32)30-26(33)14-4-7-19(28)18(27)10-14/h4-13H,1-3H3,(H,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant KDR by HTRF assay				Bioorg Med Chem Lett 18: 4844-8 (2008) Article DOI: 10.1016/j.bmcl.2008.07.080 BindingDB Entry DOI: 10.7270/Q2W9591V
					More data for this Ligand-Target Pair