Found 4 hits for monomerid = 50245443 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50245443
(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)Show SMILES COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1 Show InChI InChI=1S/C25H22ClN5O3/c1-33-19-10-7-17(8-11-19)31-25(32)22-23(27)28-15-29-24(22)30-18-9-12-21(20(26)13-18)34-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,31,32)(H3,27,28,29,30) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of HER2 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50245443
(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)Show SMILES COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1 Show InChI InChI=1S/C25H22ClN5O3/c1-33-19-10-7-17(8-11-19)31-25(32)22-23(27)28-15-29-24(22)30-18-9-12-21(20(26)13-18)34-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,31,32)(H3,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245443
(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)Show SMILES COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1 Show InChI InChI=1S/C25H22ClN5O3/c1-33-19-10-7-17(8-11-19)31-25(32)22-23(27)28-15-29-24(22)30-18-9-12-21(20(26)13-18)34-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,31,32)(H3,27,28,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50245443
(4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4...)Show SMILES COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1 Show InChI InChI=1S/C25H22ClN5O3/c1-33-19-10-7-17(8-11-19)31-25(32)22-23(27)28-15-29-24(22)30-18-9-12-21(20(26)13-18)34-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,31,32)(H3,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Aurora A (unknown origin) |
Bioorg Med Chem Lett 18: 4896-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.057 BindingDB Entry DOI: 10.7270/Q2NS0TPB |
More data for this Ligand-Target Pair | |