BDBM50248052 CHEMBL447616::N-(3-fluoro-4-(2-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide

SMILES: CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1

InChI Key: InChIKey=RIXXXEWTJFUQDB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248052   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248052 (CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...) Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248052 (CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...) Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50248052 (CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...) Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50248052 (CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...) Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay				Bioorg Med Chem Lett 19: 1323-8 (2009) Article DOI: 10.1016/j.bmcl.2009.01.068 BindingDB Entry DOI: 10.7270/Q23F4PHJ
					More data for this Ligand-Target Pair