BDBM50248697 1-(4-Aminosulfonylphenyl)-5-(2-chloropyridin-4-yl)-3-trifluoromethyl-1H-pyrazole::CHEMBL507398

SMILES: NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccnc(Cl)c1)C(F)(F)F

InChI Key: InChIKey=XXSFLLPWVZKAJO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50248697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase (Homo sapiens (Human))	BDBM50248697 (1-(4-Aminosulfonylphenyl)-5-(2-chloropyridin-4-yl)...) Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccnc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C15H10ClF3N4O2S/c16-14-7-9(5-6-21-14)12-8-13(15(17,18)19)22-23(12)10-1-3-11(4-2-10)26(20,24)25/h1-8H,(H2,20,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of human recombinant COX2 by enzyme immunoassay				J Med Chem 52: 1525-9 (2009) Article DOI: 10.1021/jm8015188 BindingDB Entry DOI: 10.7270/Q26Q1X5H
					More data for this Ligand-Target Pair
Cyclooxygenase (Bos taurus)	BDBM50248697 (1-(4-Aminosulfonylphenyl)-5-(2-chloropyridin-4-yl)...) Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccnc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C15H10ClF3N4O2S/c16-14-7-9(5-6-21-14)12-8-13(15(17,18)19)22-23(12)10-1-3-11(4-2-10)26(20,24)25/h1-8H,(H2,20,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of bovine COX1 by enzyme immunoassay				J Med Chem 52: 1525-9 (2009) Article DOI: 10.1021/jm8015188 BindingDB Entry DOI: 10.7270/Q26Q1X5H
					More data for this Ligand-Target Pair