BDBM50249904 CHEMBL4098503

SMILES: Cc1onc(c1C(=O)Nc1cccc(c1)S(=O)(=O)NCc1ccco1)-c1ccccc1

InChI Key: InChIKey=GTKAQHJSWUEEHE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249904   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GATA4/NKX2-5 (Mus musculus)	BDBM50249904 (CHEMBL4098503) Show SMILES Cc1onc(c1C(=O)Nc1cccc(c1)S(=O)(=O)NCc1ccco1)-c1ccccc1 Show InChI InChI=1S/C22H19N3O5S/c1-15-20(21(25-30-15)16-7-3-2-4-8-16)22(26)24-17-9-5-11-19(13-17)31(27,28)23-14-18-10-6-12-29-18/h2-13,23H,14H2,1H3,(H,24,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland. Curated by ChEMBL					Assay Description Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...				J Med Chem 60: 7781-7798 (2017) Article DOI: 10.1021/acs.jmedchem.7b00816 BindingDB Entry DOI: 10.7270/Q2DN47GK
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