BindingDB PrimarySearch

BDBM50250422 (+)-N-methyl-laurotetanine::CHEMBL464099::N-methyllaurotetanine

SMILES: COc1cc-2c(C[C@@H]3N(C)CCc4cc(OC)c(OC)c-2c34)cc1O

InChI Key: InChIKey=ZFLRVRLYWHNAEC-AWEZNQCLSA-N

Data: 15 KI 1 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50250422
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tom's of Maine Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells				J Nat Prod 69: 432-5 (2006) Article DOI: 10.1021/np058114h BindingDB Entry DOI: 10.7270/Q2V98907
Tom's of Maine Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	306	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	314	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]Way100635 from human recombinant 5-HT1A receptor expressed in CHO cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	323	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	373	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	566	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5-HT5A receptor expressed in Flp-In CHO cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]citalopram from human recombinant SERT expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]WIN35428 from human recombinant DAT expressed in HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human recombinant dopamine D3 receptor expressed in HEKT cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]CGP12177 from human recombinant adrenergic beta2 receptor expressed in CHO Flp-In cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from human recombinant adrenergic alpha1B receptor expressed in HEKT cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in Flp-IN HEK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
City University of New York Curated by ChEMBL					Assay Description Displacement of [3H]rauwolscine from human recombinant adrenergic alpha2C receptor expressed in MDCK cell membranes by radioligand binding assay				J Nat Prod 78: 722-9 (2015) Article DOI: 10.1021/np500893h BindingDB Entry DOI: 10.7270/Q23B61WB
City University of New York Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
Tom's of Maine Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells				J Nat Prod 69: 432-5 (2006) Article DOI: 10.1021/np058114h BindingDB Entry DOI: 10.7270/Q2V98907
Tom's of Maine Curated by ChEMBL					More data for this Ligand-Target Pair
Butyrylcholinesterase (BuChE) (Equus caballus (Horse))	BDBM50250422 ((+)-N-methyl-laurotetanine \| CHEMBL464099 \| N-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.19E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Malaya Curated by ChEMBL					Assay Description Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-butyrylthiocholine chloride as substrate measured after 30 mins by...				Bioorg Med Chem 24: 4464-4469 (2016) BindingDB Entry DOI: 10.7270/Q2MG7RFM
University of Malaya Curated by ChEMBL					More data for this Ligand-Target Pair