BDBM50252051 (2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pentanedioic acid::(2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid::CHEMBL500042
SMILES: CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
InChI Key: InChIKey=NIJAFEMYFNBSBE-RITPCOANSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor ionotropic, kainate 1 (RAT) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | 3.81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR5 | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, kainate (Rattus norvegicus) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 57.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR7 | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (Rattus norvegicus) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR6 | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 2 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | 6.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]LY43915 from rat mGluR2 expressed in CHO cells by SPA | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]LY43915 from rat mGluR3 expressed in CHO cells by SPA | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 1 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | >3.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Activity at rat mGluR2 expressed in CHO cells assessed as calcium mobilization by FLIPR | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Activity at mGluR4 assessed as calcium mobilization by FLIPR | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Activity at rat mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (RAT) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Activity at rat mGluR1 expressed in HEK293 cells assessed as calcium mobilization by FLIPR | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 2 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assay | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 1 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assay | J Med Chem 51: 4085-92 (2008) Checked by Author Article DOI: 10.1021/jm800091e BindingDB Entry DOI: 10.7270/Q24M95FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay | J Med Chem 59: 914-24 (2016) BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay | J Med Chem 59: 914-24 (2016) BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat)) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production | J Med Chem 59: 914-24 (2016) BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor (RAT) | BDBM50252051 ((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay | J Med Chem 59: 914-24 (2016) BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair |