BDBM50255947 CHEMBL4078973

SMILES: CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CC5(C4)CCN(C)CC5)c(C)c3)nc12)c1cc(OC)ccc1F

InChI Key: InChIKey=ALJUOQUASATKRZ-SANMLTNESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50255947   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50255947 (CHEMBL4078973) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CC5(C4)CCN(C)CC5)c(C)c3)nc12)c1cc(OC)ccc1F |r| Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-21-35(22-42)11-14-40(3)15-12-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50255947 (CHEMBL4078973) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CC5(C4)CCN(C)CC5)c(C)c3)nc12)c1cc(OC)ccc1F |r| Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-21-35(22-42)11-14-40(3)15-12-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	218	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair