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SMILES: O=C(CNc1cccc(OCc2ccccc2)c1)N\N=C1/CCCc2cnccc12

InChI Key: InChIKey=NZRBHDHCONKCTH-SLEBQGDGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257368   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50257368 (CHEMBL4072224) Show SMILES O=C(CNc1cccc(OCc2ccccc2)c1)N\N=C1/CCCc2cnccc12 Show InChI InChI=1S/C24H24N4O2/c29-24(28-27-23-11-4-8-19-15-25-13-12-22(19)23)16-26-20-9-5-10-21(14-20)30-17-18-6-2-1-3-7-18/h1-3,5-7,9-10,12-15,26H,4,8,11,16-17H2,(H,28,29)/b27-23+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shonan Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Curated by ChEMBL					Assay Description Inhibition of human PKCalpha active using MBP as substrate after 60 mins in presence of [gamma-32]ATP by scintillation counting				J Med Chem 60: 6942-6990 (2017) Article DOI: 10.1021/acs.jmedchem.7b00443 BindingDB Entry DOI: 10.7270/Q280552Z
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human))	BDBM50257368 (CHEMBL4072224) Show SMILES O=C(CNc1cccc(OCc2ccccc2)c1)N\N=C1/CCCc2cnccc12 Show InChI InChI=1S/C24H24N4O2/c29-24(28-27-23-11-4-8-19-15-25-13-12-22(19)23)16-26-20-9-5-10-21(14-20)30-17-18-6-2-1-3-7-18/h1-3,5-7,9-10,12-15,26H,4,8,11,16-17H2,(H,28,29)/b27-23+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Shonan Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Curated by ChEMBL					Assay Description Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...				J Med Chem 60: 6942-6990 (2017) Article DOI: 10.1021/acs.jmedchem.7b00443 BindingDB Entry DOI: 10.7270/Q280552Z
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50257368 (CHEMBL4072224) Show SMILES O=C(CNc1cccc(OCc2ccccc2)c1)N\N=C1/CCCc2cnccc12 Show InChI InChI=1S/C24H24N4O2/c29-24(28-27-23-11-4-8-19-15-25-13-12-22(19)23)16-26-20-9-5-10-21(14-20)30-17-18-6-2-1-3-7-18/h1-3,5-7,9-10,12-15,26H,4,8,11,16-17H2,(H,28,29)/b27-23+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shonan Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 to 553 residues) expressed in baculovirus expression system using STK...				J Med Chem 60: 6942-6990 (2017) Article DOI: 10.1021/acs.jmedchem.7b00443 BindingDB Entry DOI: 10.7270/Q280552Z
					More data for this Ligand-Target Pair