BDBM50258437 1-(2-methylbenzyl)-5-(trifluoromethoxy)indoline-2,3-dione::CHEMBL506043

SMILES: Cc1ccccc1CN1C(=O)C(=O)c2cc(OC(F)(F)F)ccc12

InChI Key: InChIKey=BLFLCAHRUVIFSV-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50258437 (1-(2-methylbenzyl)-5-(trifluoromethoxy)indoline-2,...) Show SMILES Cc1ccccc1CN1C(=O)C(=O)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C17H12F3NO3/c1-10-4-2-3-5-11(10)9-21-14-7-6-12(24-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.28E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell...				J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50258437 (1-(2-methylbenzyl)-5-(trifluoromethoxy)indoline-2,...) Show SMILES Cc1ccccc1CN1C(=O)C(=O)c2cc(OC(F)(F)F)ccc12 Show InChI InChI=1S/C17H12F3NO3/c1-10-4-2-3-5-11(10)9-21-14-7-6-12(24-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of rat muscarinic M1 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellul...				J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q
					More data for this Ligand-Target Pair