BDBM50258596 CHEMBL4091817

SMILES: C(NCc1cn(-c2cccc(c2)-c2ccccc2)c2ccccc12)C1CCCCC1

InChI Key: InChIKey=AEXWQRTZIUKQLU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258596   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human))	BDBM50258596 (CHEMBL4091817) Show SMILES C(NCc1cn(-c2cccc(c2)-c2ccccc2)c2ccccc12)C1CCCCC1 Show InChI InChI=1S/C28H30N2/c1-3-10-22(11-4-1)19-29-20-25-21-30(28-17-8-7-16-27(25)28)26-15-9-14-24(18-26)23-12-5-2-6-13-23/h2,5-9,12-18,21-22,29H,1,3-4,10-11,19-20H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL					Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...				J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP
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