BDBM50258847 4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine::CHEMBL449357
SMILES: COc1ccc(cc1)C1(CCCC1)c1csc(N)n1
InChI Key: InChIKey=CKMNYFMEILPBLI-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50258847![]() (4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine ...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of BACE1 (unknown origin) at pH 4.5 | Bioorg Med Chem Lett 19: 2977-80 (2009) Article DOI: 10.1016/j.bmcl.2009.04.033 BindingDB Entry DOI: 10.7270/Q2XS5V96 | |||||||||||
More data for this Ligand-Target Pair |