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BDBM50261204 CHEMBL4098255

SMILES: Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3ccc(F)c(F)c3)ncnc12

InChI Key: InChIKey=ORKSQVXJLGIROJ-IYBDPMFKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50261204   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM50261204
PNG
(CHEMBL4098255)
Show SMILES Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3ccc(F)c(F)c3)ncnc12 |r,wU:12.15,10.10,(29.23,-17.32,;28.14,-18.41,;26.65,-18.01,;25.57,-19.1,;25.97,-20.59,;27.45,-20.98,;28.54,-19.89,;27.85,-22.47,;29.36,-22.79,;26.82,-23.62,;25.31,-23.3,;24.02,-24.13,;23.19,-22.84,;24.48,-22.01,;21.68,-22.52,;21.05,-21.11,;19.52,-21.28,;19.2,-22.78,;17.87,-23.56,;16.53,-22.78,;15.2,-23.56,;13.87,-22.78,;13.87,-21.24,;12.54,-20.48,;11.2,-21.24,;9.86,-20.48,;11.2,-22.78,;9.86,-23.56,;12.54,-23.56,;17.87,-25.09,;19.2,-25.86,;20.53,-25.09,;20.53,-23.56,)|
Show InChI InChI=1S/C23H21F2N7O/c1-13-3-2-4-19(30-13)23(33)31-15-8-16(9-15)32-12-29-20-21(27-11-28-22(20)32)26-10-14-5-6-17(24)18(25)7-14/h2-7,11-12,15-16H,8-10H2,1H3,(H,31,33)(H,26,27,28)/t15-,16+
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MMDB

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Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of CDK2/CyclinA (unknown origin) using ULingt-4E-BP as substrate after 1 hr in presence of ATP by fluorescence assay


Bioorg Med Chem Lett 27: 4399-4404 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.018
BindingDB Entry DOI: 10.7270/Q2W66P60
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50261204
PNG
(CHEMBL4098255)
Show SMILES Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3ccc(F)c(F)c3)ncnc12 |r,wU:12.15,10.10,(29.23,-17.32,;28.14,-18.41,;26.65,-18.01,;25.57,-19.1,;25.97,-20.59,;27.45,-20.98,;28.54,-19.89,;27.85,-22.47,;29.36,-22.79,;26.82,-23.62,;25.31,-23.3,;24.02,-24.13,;23.19,-22.84,;24.48,-22.01,;21.68,-22.52,;21.05,-21.11,;19.52,-21.28,;19.2,-22.78,;17.87,-23.56,;16.53,-22.78,;15.2,-23.56,;13.87,-22.78,;13.87,-21.24,;12.54,-20.48,;11.2,-21.24,;9.86,-20.48,;11.2,-22.78,;9.86,-23.56,;12.54,-23.56,;17.87,-25.09,;19.2,-25.86,;20.53,-25.09,;20.53,-23.56,)|
Show InChI InChI=1S/C23H21F2N7O/c1-13-3-2-4-19(30-13)23(33)31-15-8-16(9-15)32-12-29-20-21(27-11-28-22(20)32)26-10-14-5-6-17(24)18(25)7-14/h2-7,11-12,15-16H,8-10H2,1H3,(H,31,33)(H,26,27,28)/t15-,16+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p35 (unknown origin) using ULingt-4E-BP as substrate after 1 hr in presence of ATP by fluorescence assay


Bioorg Med Chem Lett 27: 4399-4404 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.018
BindingDB Entry DOI: 10.7270/Q2W66P60
More data for this
Ligand-Target Pair