BDBM50263004 CHEMBL4069936
SMILES: Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O
InChI Key: InChIKey=WLQXBRYTQYYCMW-REWPJTCUSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50263004 (CHEMBL4069936) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai... | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Rattus norvegicus) | BDBM50263004 (CHEMBL4069936) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of rat SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst staini... | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50263004 (CHEMBL4069936) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r... | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2B (Homo sapiens) | BDBM50263004 (CHEMBL4069936) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of human SPPL2b expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai... | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Mus musculus) | BDBM50263004 (CHEMBL4069936) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Mus musculus) | BDBM50263004 (CHEMBL4069936) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL | Assay Description Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai... | J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49 | |||||||||||
More data for this Ligand-Target Pair |