BDBM50263007 CHEMBL4076827

SMILES: C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O

InChI Key: InChIKey=RMAOZJWPQJSLBK-SZNDQCEHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263007   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot method				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair