BDBM50265500 (S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate::CHEMBL449276::tert-Butyl (2S)-2-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate
SMILES: CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
InChI Key: InChIKey=FCXCNDHEICKHMB-QHCPKHFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene protein Wnt-3 (Homo sapiens (Human)) | BDBM50265500 ((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay | J Med Chem 52: 105-16 (2009) Article DOI: 10.1021/jm801144h BindingDB Entry DOI: 10.7270/Q2NZ87HT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Secreted frizzled-related protein 1 (Homo sapiens (Human)) | BDBM50265500 ((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assay | Bioorg Med Chem 18: 190-201 (2010) Article DOI: 10.1016/j.bmc.2009.11.002 BindingDB Entry DOI: 10.7270/Q2PZ58Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Secreted frizzled-related protein 1 (Homo sapiens (Human)) | BDBM50265500 ((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g... | Bioorg Med Chem 18: 190-201 (2010) Article DOI: 10.1016/j.bmc.2009.11.002 BindingDB Entry DOI: 10.7270/Q2PZ58Z7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Secreted frizzled-related protein 1 (Homo sapiens (Human)) | BDBM50265500 ((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Binding affinity to human purified SARP2 by fluorescent polarization assay | J Med Chem 52: 105-16 (2009) Article DOI: 10.1021/jm801144h BindingDB Entry DOI: 10.7270/Q2NZ87HT | |||||||||||
More data for this Ligand-Target Pair |