BDBM50265599 CHEMBL4097731

SMILES: Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2c(Br)cccc12

InChI Key: InChIKey=UXYJOCDFRUXVOF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265599   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265599 (CHEMBL4097731) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2c(Br)cccc12 Show InChI InChI=1S/C25H19BrCl2N4O2/c26-23-3-1-2-21-20(14-29-32(21)23)25(34)30-12-13-31(24(33)17-6-10-19(28)11-7-17)22(15-30)16-4-8-18(27)9-5-16/h1-11,14,22H,12-13,15H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
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