BDBM50265844 3-(2-(4-(4-isopropylpiperazin-1-yl)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxamide::CHEMBL514718

SMILES: COc1cc(ccc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C

InChI Key: InChIKey=PGLGFLNSPUHDGR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265844   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50265844 (3-(2-(4-(4-isopropylpiperazin-1-yl)-2-methoxypheny...) Show SMILES COc1cc(ccc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C25H30N8O2S/c1-15(2)32-9-11-33(12-10-32)16-4-5-18(20(14-16)35-3)29-25-30-23-17(6-8-27-23)24(31-25)28-19-7-13-36-21(19)22(26)34/h4-8,13-15H,9-12H2,1-3H3,(H2,26,34)(H3,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50265844 (3-(2-(4-(4-isopropylpiperazin-1-yl)-2-methoxypheny...) Show SMILES COc1cc(ccc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C25H30N8O2S/c1-15(2)32-9-11-33(12-10-32)16-4-5-18(20(14-16)35-3)29-25-30-23-17(6-8-27-23)24(31-25)28-19-7-13-36-21(19)22(26)34/h4-8,13-15H,9-12H2,1-3H3,(H2,26,34)(H3,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of IGF1R phosphorylation by cellular assay				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair