BDBM50265847 3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)furan-2-carboxamide::CHEMBL458414
SMILES: COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccoc2C(N)=O)c2cc[nH]c2n1
InChI Key: InChIKey=ILSXVNQDNROHLJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50265847 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265847
(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccoc2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H28N8O4/c1-32(2)13-20(34)33-9-4-5-14-11-19(36-3)17(12-18(14)33)29-25-30-23-15(6-8-27-23)24(31-25)28-16-7-10-37-21(16)22(26)35/h6-8,10-12H,4-5,9,13H2,1-3H3,(H2,26,35)(H3,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50265847
(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccoc2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H28N8O4/c1-32(2)13-20(34)33-9-4-5-14-11-19(36-3)17(12-18(14)33)29-25-30-23-15(6-8-27-23)24(31-25)28-16-7-10-37-21(16)22(26)35/h6-8,10-12H,4-5,9,13H2,1-3H3,(H2,26,35)(H3,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R phosphorylation by cellular assay |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |