BDBM50267820 (4-(biphenyl-3-ylsulfonyl)piperazin-1-yl)(cyclohexyl)methanone::CHEMBL490043

SMILES: O=C(C1CCCCC1)N1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccccc1

InChI Key: InChIKey=PLDPMGKDBWCPST-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267820   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50267820 ((4-(biphenyl-3-ylsulfonyl)piperazin-1-yl)(cyclohex...) Show SMILES O=C(C1CCCCC1)N1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C23H28N2O3S/c26-23(20-10-5-2-6-11-20)24-14-16-25(17-15-24)29(27,28)22-13-7-12-21(18-22)19-8-3-1-4-9-19/h1,3-4,7-9,12-13,18,20H,2,5-6,10-11,14-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human recombinant CB2R expressed in CHO cells				J Med Chem 52: 2550-8 (2009) Article DOI: 10.1021/jm900063x BindingDB Entry DOI: 10.7270/Q2028RF8
					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50267820 ((4-(biphenyl-3-ylsulfonyl)piperazin-1-yl)(cyclohex...) Show SMILES O=C(C1CCCCC1)N1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C23H28N2O3S/c26-23(20-10-5-2-6-11-20)24-14-16-25(17-15-24)29(27,28)22-13-7-12-21(18-22)19-8-3-1-4-9-19/h1,3-4,7-9,12-13,18,20H,2,5-6,10-11,14-17H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inverse agonist activity at human recombinant CB1R expressed in CHO cells assessed as increase in forskolin-stimulated cAMP level				J Med Chem 52: 2550-8 (2009) Article DOI: 10.1021/jm900063x BindingDB Entry DOI: 10.7270/Q2028RF8
					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50267820 ((4-(biphenyl-3-ylsulfonyl)piperazin-1-yl)(cyclohex...) Show SMILES O=C(C1CCCCC1)N1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C23H28N2O3S/c26-23(20-10-5-2-6-11-20)24-14-16-25(17-15-24)29(27,28)22-13-7-12-21(18-22)19-8-3-1-4-9-19/h1,3-4,7-9,12-13,18,20H,2,5-6,10-11,14-17H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human recombinant CB1R expressed in CHO cells				J Med Chem 52: 2550-8 (2009) Article DOI: 10.1021/jm900063x BindingDB Entry DOI: 10.7270/Q2028RF8
					More data for this Ligand-Target Pair