BDBM50268063 (E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinolinyl)-2-propenamide::CHEMBL484073

SMILES: ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1

InChI Key: InChIKey=IXKLILPHPNZHNB-CSKARUKUSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50268063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 5 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC5				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC1				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC2				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC3				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC9				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC6				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC7				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC8				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50268063 ((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...) Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1 Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC4				Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX
					More data for this Ligand-Target Pair