null

SMILES: N#Cc1ccc(cc1)C1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12

InChI Key: InChIKey=ZCBPOKGVMMAGFY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50268660   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Smoothened homolog (Mus musculus)	BDBM50268660 (4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzo...) Show SMILES N#Cc1ccc(cc1)C1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C27H24N4/c28-19-21-10-12-22(13-11-21)23-14-16-31(17-15-23)27-25-9-5-4-8-24(25)26(29-30-27)18-20-6-2-1-3-7-20/h1-13,23H,14-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...				J Med Chem 52: 3954-68 (2009) Article DOI: 10.1021/jm900309j BindingDB Entry DOI: 10.7270/Q2CN73T7
					More data for this Ligand-Target Pair
Smoothened homolog (Homo sapiens (Human))	BDBM50268660 (4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzo...) Show SMILES N#Cc1ccc(cc1)C1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C27H24N4/c28-19-21-10-12-22(13-11-21)23-14-16-31(17-15-23)27-25-9-5-4-8-24(25)26(29-30-27)18-20-6-2-1-3-7-20/h1-13,23H,14-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...				J Med Chem 52: 3954-68 (2009) Article DOI: 10.1021/jm900309j BindingDB Entry DOI: 10.7270/Q2CN73T7
					More data for this Ligand-Target Pair
Smoothened homolog (Mus musculus)	BDBM50268660 (4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzo...) Show SMILES N#Cc1ccc(cc1)C1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C27H24N4/c28-19-21-10-12-22(13-11-21)23-14-16-31(17-15-23)27-25-9-5-4-8-24(25)26(29-30-27)18-20-6-2-1-3-7-20/h1-13,23H,14-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...				J Med Chem 52: 3954-68 (2009) Article DOI: 10.1021/jm900309j BindingDB Entry DOI: 10.7270/Q2CN73T7
					More data for this Ligand-Target Pair
Smoothened homolog (Mus musculus)	BDBM50268660 (4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzo...) Show SMILES N#Cc1ccc(cc1)C1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C27H24N4/c28-19-21-10-12-22(13-11-21)23-14-16-31(17-15-23)27-25-9-5-4-8-24(25)26(29-30-27)18-20-6-2-1-3-7-20/h1-13,23H,14-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...				J Med Chem 52: 3954-68 (2009) Article DOI: 10.1021/jm900309j BindingDB Entry DOI: 10.7270/Q2CN73T7
					More data for this Ligand-Target Pair