Found 8 hits for monomerid = 50271848 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) expressed in human tumor cells |
Bioorg Med Chem 16: 5514-28 (2008)
Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 (unknown origin) expressed in human tumor cells |
Bioorg Med Chem 16: 5514-28 (2008)
Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) expressed in human tumor cells |
Bioorg Med Chem 16: 5514-28 (2008)
Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of EGFR |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 |
Bioorg Med Chem Lett 20: 3177-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.064 BindingDB Entry DOI: 10.7270/Q23R0T2Z |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50271848
(6-phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrr...)Show SMILES Nc1nc(Nc2cccc(c2)C(F)(F)F)c2cc(CCc3ccccc3)[nH]c2n1 Show InChI InChI=1S/C21H18F3N5/c22-21(23,24)14-7-4-8-15(11-14)26-18-17-12-16(27-19(17)29-20(25)28-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H4,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta (unknown origin) expressed in human tumor cells |
Bioorg Med Chem 16: 5514-28 (2008)
Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D |
More data for this Ligand-Target Pair | |