BindingDB logo
myBDB logout

BDBM50272101 (E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[2,1-b]thiazole::CHEMBL505610

SMILES: C(=C/c1ccncn1)\c1c(nc2sccn12)-c1ccccc1

InChI Key: InChIKey=MRJKXXDKYLGLRQ-VOTSOKGWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272101   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50272101
PNG
((E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[...)
Show SMILES C(=C/c1ccncn1)\c1c(nc2sccn12)-c1ccccc1
Show InChI InChI=1S/C17H12N4S/c1-2-4-13(5-3-1)16-15(21-10-11-22-17(21)20-16)7-6-14-8-9-18-12-19-14/h1-12H/b7-6+
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt1 (unknown origin) expressed in baculovirus-Sf21 system


Bioorg Med Chem Lett 18: 4723-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.106
BindingDB Entry DOI: 10.7270/Q2SJ1KD2
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50272101
PNG
((E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[...)
Show SMILES C(=C/c1ccncn1)\c1c(nc2sccn12)-c1ccccc1
Show InChI InChI=1S/C17H12N4S/c1-2-4-13(5-3-1)16-15(21-10-11-22-17(21)20-16)7-6-14-8-9-18-12-19-14/h1-12H/b7-6+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant Tie2 (unknown origin) expressed in baculovirus-Sf21 system


Bioorg Med Chem Lett 18: 4723-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.106
BindingDB Entry DOI: 10.7270/Q2SJ1KD2
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50272101
PNG
((E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[...)
Show SMILES C(=C/c1ccncn1)\c1c(nc2sccn12)-c1ccccc1
Show InChI InChI=1S/C17H12N4S/c1-2-4-13(5-3-1)16-15(21-10-11-22-17(21)20-16)7-6-14-8-9-18-12-19-14/h1-12H/b7-6+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR (unknown origin) expressed in baculovirus-Sf21 system


Bioorg Med Chem Lett 18: 4723-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.106
BindingDB Entry DOI: 10.7270/Q2SJ1KD2
More data for this
Ligand-Target Pair