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BDBM50273402 5-(2-Hydroxypropan-2-yl)-5-methyl-2-[(S)-1-p-tolylethylamino]thiazol-4(5H)-one::CHEMBL506519

SMILES: C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccc(C)cc1

InChI Key: InChIKey=HGSBDCITWIZCAS-CHPOKUKFSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50273402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50273402
PNG
(5-(2-Hydroxypropan-2-yl)-5-methyl-2-[(S)-1-p-tolyl...)
Show SMILES C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccc(C)cc1 |r,t:3|
Show InChI InChI=1S/C16H22N2O2S/c1-10-6-8-12(9-7-10)11(2)17-14-18-13(19)16(5,21-14)15(3,4)20/h6-9,11,20H,1-5H3,(H,17,18,19)/t11-,16?/m0/s1
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MMDB

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Similars

Article
PubMed
130n/an/an/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay


J Med Chem 51: 7953-67 (2008)


Article DOI: 10.1021/jm801073z
BindingDB Entry DOI: 10.7270/Q2FJ2GN7
More data for this
Ligand-Target Pair