BDBM50273884 CHEMBL4127223

SMILES: Cn1ncc2cc(ccc12)-c1ncc(cn1)C1=NC2(CC2)C(=O)N1C[C@@H]1CCN(C1)C(=O)C1CC1

InChI Key: InChIKey=DFCVEUIQWSMCKO-MRXNPFEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50273884   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM50273884 (CHEMBL4127223) Show SMILES Cn1ncc2cc(ccc12)-c1ncc(cn1)C1=NC2(CC2)C(=O)N1C[C@@H]1CCN(C1)C(=O)C1CC1 |r,t:19| Show InChI InChI=1S/C26H27N7O2/c1-31-21-5-4-18(10-19(21)13-29-31)22-27-11-20(12-28-22)23-30-26(7-8-26)25(35)33(23)15-16-6-9-32(14-16)24(34)17-2-3-17/h4-5,10-13,16-17H,2-3,6-9,14-15H2,1H3/t16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of human full length FASN using [3H]-acetyl-CoA/malonyl-CoA as substrate after 60 mins in presence of NADPH by scintillation proximity ass...				Bioorg Med Chem Lett 28: 2159-2164 (2018) Article DOI: 10.1016/j.bmcl.2018.05.014 BindingDB Entry DOI: 10.7270/Q2FB55FW
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