BDBM50274652 3-(4-[(1-Cyclobutyl-4-azepanyl)oxy]phenyl)-2-methyl-4(3H)-quinazolinone::CHEMBL485242

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCCN(CC2)C2CCC2)cc1

InChI Key: InChIKey=QILACADJNNDLKC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274652   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50274652 (3-(4-[(1-Cyclobutyl-4-azepanyl)oxy]phenyl)-2-methy...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCCN(CC2)C2CCC2)cc1 Show InChI InChI=1S/C25H29N3O2/c1-18-26-24-10-3-2-9-23(24)25(29)28(18)20-11-13-22(14-12-20)30-21-8-5-16-27(17-15-21)19-6-4-7-19/h2-3,9-14,19,21H,4-8,15-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274652 (3-(4-[(1-Cyclobutyl-4-azepanyl)oxy]phenyl)-2-methy...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCCN(CC2)C2CCC2)cc1 Show InChI InChI=1S/C25H29N3O2/c1-18-26-24-10-3-2-9-23(24)25(29)28(18)20-11-13-22(14-12-20)30-21-8-5-16-27(17-15-21)19-6-4-7-19/h2-3,9-14,19,21H,4-8,15-17H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair