BDBM50278499 4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrimidin-2-ylamino)benzenesulfonamide::CHEMBL513716
SMILES: NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4c(F)cccc4F)c3s2)cc1
InChI Key: InChIKey=HGZQTJZFKROIJB-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 1 (Homo sapiens (Human)) | BDBM50278499 (4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrim...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC Curated by ChEMBL | Assay Description Inhibition of CDK1 (unknown origin) | Bioorg Med Chem Lett 19: 2333-7 (2009) Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50278499 (4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrim...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC Curated by ChEMBL | Assay Description Inhibition of EGFR (unknown origin) | Bioorg Med Chem Lett 19: 2333-7 (2009) Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 | |||||||||||
More data for this Ligand-Target Pair |