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BDBM50279858 (3R,5R)-7-(2-Benzyloxy-4,6-dichloro-phenyl)-3,5-dihydroxy-heptanoic acid::CHEMBL39312

SMILES: O[C@H](CCc1c(Cl)cc(Cl)cc1OCc1ccccc1)C[C@@H](O)CC(O)=O

InChI Key: InChIKey=VWKZOIOUHUHQKZ-HZPDHXFCSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50279858   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)


(Homo sapiens (Human))
BDBM50279858
PNG
((3R,5R)-7-(2-Benzyloxy-4,6-dichloro-phenyl)-3,5-di...)
Show SMILES O[C@H](CCc1c(Cl)cc(Cl)cc1OCc1ccccc1)C[C@@H](O)CC(O)=O
Show InChI InChI=1S/C20H22Cl2O5/c21-14-8-18(22)17(7-6-15(23)10-16(24)11-20(25)26)19(9-14)27-12-13-4-2-1-3-5-13/h1-5,8-9,15-16,23-24H,6-7,10-12H2,(H,25,26)/t15-,16-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem
Article
3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The inhibitory activity of the compound against purified recombinant human HMG-CoA reductase was evaluated


Bioorg Med Chem Lett 1: 151-154 (1991)


Article DOI: 10.1016/S0960-894X(01)80788-5
BindingDB Entry DOI: 10.7270/Q21836DP
More data for this
Ligand-Target Pair