BDBM50284444 CHEMBL15689::[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2-propyl-phenoxy]-phenyl-acetic acid

SMILES: CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(O)=O)c1ccccc1

InChI Key: InChIKey=IFUYEJOQMQZCAE-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50284444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50284444 (CHEMBL15689 | [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5...) Show SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(O)=O)c1ccccc1 Show InChI InChI=1S/C28H31N3O3/c1-5-10-22-16-20(13-14-23(22)34-26(28(32)33)21-11-8-7-9-12-21)17-31-24(6-2)30-25-18(3)15-19(4)29-27(25)31/h7-9,11-16,26H,5-6,10,17H2,1-4H3,(H,32,33)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)				Bioorg Med Chem Lett 5: 1151-1154 (1995) Article DOI: 10.1016/0960-894X(95)00185-V BindingDB Entry DOI: 10.7270/Q2J67GV9
					More data for this Ligand-Target Pair
EDNRB (Homo sapiens (Human))	BDBM50284444 (CHEMBL15689 | [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5...) Show SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(O)=O)c1ccccc1 Show InChI InChI=1S/C28H31N3O3/c1-5-10-22-16-20(13-14-23(22)34-26(28(32)33)21-11-8-7-9-12-21)17-31-24(6-2)30-25-18(3)15-19(4)29-27(25)31/h7-9,11-16,26H,5-6,10,17H2,1-4H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human endothelin B (ETB) receptor expressed in CHO cells				Bioorg Med Chem Lett 5: 1155-1158 (1995) Article DOI: 10.1016/0960-894X(95)00186-W BindingDB Entry DOI: 10.7270/Q2DF6R5F
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50284444 (CHEMBL15689 | [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5...) Show SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(O)=O)c1ccccc1 Show InChI InChI=1S/C28H31N3O3/c1-5-10-22-16-20(13-14-23(22)34-26(28(32)33)21-11-8-7-9-12-21)17-31-24(6-2)30-25-18(3)15-19(4)29-27(25)31/h7-9,11-16,26H,5-6,10,17H2,1-4H3,(H,32,33)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human endothelin A (ETA) receptor expressed in CHO cells				Bioorg Med Chem Lett 5: 1155-1158 (1995) Article DOI: 10.1016/0960-894X(95)00186-W BindingDB Entry DOI: 10.7270/Q2DF6R5F
					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50284444 (CHEMBL15689 | [4-(2-Ethyl-5,7-dimethyl-imidazo[4,5...) Show SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(O)=O)c1ccccc1 Show InChI InChI=1S/C28H31N3O3/c1-5-10-22-16-20(13-14-23(22)34-26(28(32)33)21-11-8-7-9-12-21)17-31-24(6-2)30-25-18(3)15-19(4)29-27(25)31/h7-9,11-16,26H,5-6,10,17H2,1-4H3,(H,32,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)				Bioorg Med Chem Lett 5: 1151-1154 (1995) Article DOI: 10.1016/0960-894X(95)00185-V BindingDB Entry DOI: 10.7270/Q2J67GV9
					More data for this Ligand-Target Pair