BDBM50286012 3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-1H-indole-3-carbonyl]-1H-pyrrolo[1,2-c]thiazol-3-yl}-1-hydroxy-pyridinium::6-(4-Fluoro-phenyl)-3-[(R)-3-(1-oxy-pyridin-3-yl)-1H-pyrrolo[1,2-c]thiazole-7-carbonyl]-indole-1-carboxylic acid dimethylamide::CHEMBL317745
SMILES: CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+]([O-])c2)c2ccc(cc12)-c1ccc(F)cc1
InChI Key: InChIKey=OFLJSMFGGYPWAQ-MUUNZHRXSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PTAFR (RAT) | BDBM50286012 (3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of platelet activating factor(PAF) by binding to PAF receptor | Bioorg Med Chem Lett 5: 2909-2912 (1995) Article DOI: 10.1016/0960-894X(95)00510-Z BindingDB Entry DOI: 10.7270/Q2S46RXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Cavia porcellus) | BDBM50286012 (3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes | Bioorg Med Chem Lett 5: 2913-2918 (1995) Article DOI: 10.1016/0960-894X(95)00511-Q BindingDB Entry DOI: 10.7270/Q2NC6157 | |||||||||||
More data for this Ligand-Target Pair |