null

SMILES: CS(=O)(=O)c1ccc(cc1)-c1sc2nc(nn2c1-c1ccccc1)C(F)(F)F

InChI Key: InChIKey=SWKWTJVJCSGVET-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50289328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50289328 (5-(4-Methanesulfonyl-phenyl)-6-phenyl-2-trifluorom...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sc2nc(nn2c1-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H12F3N3O2S2/c1-28(25,26)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)24-17(27-15)22-16(23-24)18(19,20)21/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells				Bioorg Med Chem Lett 7: 57-62 (1997) Article DOI: 10.1016/S0960-894X(96)00582-3 BindingDB Entry DOI: 10.7270/Q29W0FG1
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50289328 (5-(4-Methanesulfonyl-phenyl)-6-phenyl-2-trifluorom...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sc2nc(nn2c1-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H12F3N3O2S2/c1-28(25,26)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)24-17(27-15)22-16(23-24)18(19,20)21/h2-10H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
The M.S University of Baroda Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 expressed in CHO-K1 cells using arachidonic acid as substrate preincubated for 15 mins followed by substrate ad...				Eur J Med Chem 162: 1-17 (2019) Article DOI: 10.1016/j.ejmech.2018.10.054 BindingDB Entry DOI: 10.7270/Q2FX7DSW
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50289328 (5-(4-Methanesulfonyl-phenyl)-6-phenyl-2-trifluorom...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sc2nc(nn2c1-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H12F3N3O2S2/c1-28(25,26)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)24-17(27-15)22-16(23-24)18(19,20)21/h2-10H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3.02E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of COX2 (unknown origin) expressed in CHO cells				Citation and Details Article DOI: 10.1007/s00044-004-0039-1 BindingDB Entry DOI: 10.7270/Q2280BHV
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50289328 (5-(4-Methanesulfonyl-phenyl)-6-phenyl-2-trifluorom...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1sc2nc(nn2c1-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H12F3N3O2S2/c1-28(25,26)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)24-17(27-15)22-16(23-24)18(19,20)21/h2-10H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells				Bioorg Med Chem Lett 7: 57-62 (1997) Article DOI: 10.1016/S0960-894X(96)00582-3 BindingDB Entry DOI: 10.7270/Q29W0FG1
					More data for this Ligand-Target Pair